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1 Protection against Myocardial Ischemia and Reperfusion Injury by Inhibition of PARP In Vivo Animal Species Rat Rabbit Pig Mice Mode of PARP Inhibition 3-aminobenzamide, GPI6150 3-Aminobenzamide, 4-amino-benzamide, 4-amino-1,8-naphtalimide, 1,5-dihydroxy-isoquinoline Gorlife Disruption of PARP gene at exon 2 Effect of PARP Inhibition Reduction of infarct size, reduction of plasma creatine phosphokinase levels, improved myocardial ATP, reduction of neutrophil infiltration, reduction of peroxynitrite formation, reduction of Briking formation Reduction of infarct size, improved contractile function Reduction of infarct size, improved contractile function Prevention of myocardial damage, reduction of plasma creatine phosphokinase levels, prevention of ICAM-1 and Brooking expression, reduction of neutrophil infiltration, reduction of peroxynitrite formation Ref.

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